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Hormone Replacement Therapy (HRT)

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For many years, women have been prescribed Estrogen with or without Progestin Hormone Replacement Therapy (HRT) to relieve some of the symptoms of menopause. However, recent scientific studies have identified significant risks associated with this therapy.

 

Hormone Replacement Therapy Drugs

HRT products have been approved by Health Canada to treat menopausal symptoms such as hot flashes, night sweats, vaginal dryness and in some cases, to prevent osteoporosis. While there are other forms of hormone replacement available, such as the patch, gel and vaginal ring, HRT is most commonly taken in pill form, of which there are two main types:

 

Progestin is added for the prevention of uterine cancer in women who have not had a hysterectomy (surgical removal of the uterus).

 

Some earlier studies suggested that the use of HRT products might help to prevent heart disease in post-menopausal women. But the lower incidence of heart disease among these women is now believed to be due to other factors such as diet and lifestyle. The labelling materials approved by Health Canada for HRT products clearly state that they have not been approved for the prevention of heart attack, stroke or any other cardiovascular disorder.

 

The Health Risks and Benefits of Hormone Replacement Therapy

In 1991, the U.S. National Institutes of Health (NIH) launched the Women's Health Initiative (WHI), a set of studies involving healthy post-menopausal women that was carried out in 40 U.S. centres. The WHI included a clinical trial to evaluate the risks and benefits of the two types of HRT (administered in pill form) and to see how they affected the incidence of heart disease, breast cancer, colorectal cancer and fractures in post-menopausal women. The trial was divided into two arms. One arm involved more than 16,000 post-menopausal women aged 50 to 79 who had not had a hysterectomy. They took pills daily that were either a combination of estrogen (equine conjugated estrogens 0.625 milligrams) and progestin (medroxyprogesterone acetate 2.5 milligrams), or a placebo (pills with only inactive ingredients).

 

The second arm involved more than 10,000 women who had received a hysterectomy and who took estrogen pills alone or a placebo.

 

In July 2002, after an average 5.2 years of regular follow-up, the NIH prematurely ended the combined (estrogen and progestin) HRT arm of the WHI trial. An independent monitoring board, which regularly reviewed the findings, concluded that there were more risks than benefits among the group using combined HRT, compared with the placebo group. The study found that changes in the incidence of disease per 10,000 women on combined HRT in one year were:

 

While these numbers appear to be low, they are highly significant. Given that millions of women are taking combined HRT, the number affected over many years is an important public health issue.

 

Since July, 2002, further results from the Women's Health Initiative trial have been published. Among the findings:

 

In light of these results, combined estrogen and progestin are not recommended for long-term use in post-menopausal women, except in limited circumstances where other therapeutic choices are found inadequate. The risks of breast cancer, blood clots, stroke, coronary heart disease and dementia (in women aged 65 and over) are considered to outweigh the benefits of fracture reduction and the reduced risk of colorectal cancer, when long term use of HRT is considered.

 

In March 2004, the estrogen- only arm HRT was discontinued. After nearly seven years of follow-up, NIH reported that estrogen therapy:

 

In the sub-study of women 65 years of age and older, estrogen was reported to show trend toward increased risk of probable dementia and mild cognitive impairment. This information will be updated as more data becomes available.

 

Please note that other dosage levels of HRT (Estrogen with or without Progestin) and other forms, such as the patch, gel or vaginal ring, were not examined in this study.

 

Minimizing Your Health Risk when taking Hormone Replacement medications

The decision to use HRT should be based on your particular needs and health, and made after a careful medical evaluation. If you are taking or considering taking HRT, you should:

 

You should not use HRT (Estrogen with or without Progestin) for the prevention or treatment of coronary heart disease or stroke.

 

HRT (Estrogen with or without Progestin) is effective for the control of hot flashes, night sweats and vaginal dryness. However, even short-term use is associated with an increased risk of blood clots, stroke and coronary heart disease. HRT should only be used if your symptoms are severe and if you have been fully informed of the risks. HRT requires regular medical evaluation.